Primary Identifier | MGI:1929091 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 56306 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of cell differentiation and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Is expressed in several structures, including central nervous system; early embryo; gut; heart; and lung. Orthologous to human SINHCAF (SIN3-HDAC complex associated factor). PHENOTYPE: Homozygous null mice exhibit hypoplasia of visceral organs and die after E10.5 but before birth. Embryos exhibit growth retardation, cardiac defects, neural tube defects, gut rotation abnormalities, and incomplete lobulation of lungs. [provided by MGI curators] |