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Protein Coding Gene : Dennd5b DENN domain containing 5B
Primary Identifier  MGI:2444273 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  320560
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B).
PHENOTYPE: Knockout decreases triglyceride absorption, and reduces susceptibility to weight gain and atherosclerosis when fed Western diet. Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]
  • synonyms:
  • MGI:2141506,
  • RIKEN cDNA D030011O10 gene,
  • AI852444,
  • D030011O10Rik,
  • ENSMUSG00000072657,
  • Dennd5b,
  • DENN domain containing 5B,
  • 9330160C06Rik,
  • MGI:2442876,
  • MGI:3641775,
  • expressed sequence AI852444,
  • RIKEN cDNA 9330160C06 gene,
  • predicted gene, ENSMUSG00000072657
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