| Primary Identifier | MGI:1932376 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 81905 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium channel regulator activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in postsynaptic density. Part of L-type voltage-gated calcium channel complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina. Used to study antisocial personality disorder. Orthologous to human CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8). PHENOTYPE: Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
