Primary Identifier | MGI:2442280 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 245126 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell proliferation and positive regulation of cytokine production involved in inflammatory response. Located in plasma membrane. Orthologous to human TARM1 (T cell-interacting, activating receptor on myeloid cells 1). PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to collagen-induced arthritis with dendritic cells showing impaired antigen presentation. [provided by MGI curators] |