Primary Identifier | MGI:105492 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 52855 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in immune response-regulating signaling pathway. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). PHENOTYPE: Mice homozygous for a knock-out allele are healthy and of normal longevity but show increased numbers of splenic B, regulatory T, and dendritic cells, and eosinophilia at a young age. Aging homozygotes display a higher frequency of activated and effector/memory T cells and a decreased IgG1 level. [provided by MGI curators] |