| Primary Identifier | MGI:1890378 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 65020 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables neurotrophin p75 receptor binding activity. Involved in neuron apoptotic process and regulation of JNK cascade. Acts upstream of or within extrinsic apoptotic signaling pathway and retinal cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in central nervous system; early conceptus; eye; genitourinary system; and liver. Orthologous to human ZNF274 (zinc finger protein 274). PHENOTYPE: Homozygous mutants on a C57BL/6 background die at embryonic day 12. On a strain 129 background, mutants are viable and fertile, but males are more docile and testis weight is greatly reduced. On an F2 background, 20% of homozygous pups die neonatally. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
