| Primary Identifier | MGI:109274 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 21849 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity; protein kinase activity; and transcription coactivator activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; epithelial to mesenchymal transition; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including convergent extension involved in axis elongation; embryo implantation; and negative regulation of RNA biosynthetic process. Located in euchromatin; heterochromatin; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb primordium. Orthologous to human TRIM28 (tripartite motif containing 28). PHENOTYPE: Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5. Conditional homozygous KO in ovaries leads to masculinization of follicles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
