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Protein Coding Gene : Nop53 NOP53 ribosome biogenesis factor
Primary Identifier  MGI:2154441 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  68077
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in negative regulation of signal transduction by p53 class mediator; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein localization to nucleolus. Located in nucleolus. Is expressed in nucleus pulposus. Orthologous to human NOP53 (NOP53 ribosome biogenesis factor).
PHENOTYPE: Homozygous knockout is pre-implantation embryonic lethal. Heterozygous knockout reduces incidence of chemically induced skin papilloma. [provided by MGI curators]
  • synonyms:
  • Gltscr2,
  • MGI:5829801,
  • expressed sequence AW536441,
  • MGI:1924654,
  • AW536441,
  • Nop53,
  • RIKEN cDNA 9430097C02 gene,
  • MGI:2138595,
  • glioma tumor suppressor candidate region gene 2,
  • NOP53 ribosome biogenesis factor,
  • MGI:1915327,
  • 9430097C02Rik,
  • RIKEN cDNA 5330430H08 gene,
  • 5330430H08Rik
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