Primary Identifier | MGI:2154263 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 243842 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 12. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). PHENOTYPE: Mice homozygous for a null allele exhibit lethality between E15 and E16.5 associated with cardiac defects, growth retardation, and edema. Mice heterozygous for the allele exhibit reduced size and weight with reduced growth hormone levels. [provided by MGI curators] |