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Protein Coding Gene : Dact3 dishevelled-binding antagonist of beta-catenin 3

Primary Identifier  MGI:3654828 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  629378
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables several functions, including delta-catenin binding activity; identical protein binding activity; and protein kinase C binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and negative regulation of epithelial to mesenchymal transition. Located in cytoplasm. Is expressed in several structures, including branchial arch artery; central nervous system; embryo mesenchyme; genitourinary system; and tooth. Orthologous to human DACT3 (dishevelled binding antagonist of beta catenin 3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit mild growth retardation and aggravated unitaleral obstruction-mediated fibrosis. [provided by MGI curators]
  • synonyms:
  • predicted gene, EG666671,
  • EG666671,
  • MGI:3646983,
  • dishevelled-binding antagonist of beta-catenin 3,
  • Dact3

Features --> Cross References

Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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Literature

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