| Primary Identifier | MGI:1345092 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 21946 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in alimentary system; craniocervical region bone; genitourinary system; liver; and respiratory system. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). PHENOTYPE: Homozygous mutant mice show a defect in neutrophil killing and increased susceptibility to infection with non-pathogenic gram-positive bacteria or DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
