| Primary Identifier | MGI:1347477 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 15377 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II and spermatogenesis. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; intracellular glucose homeostasis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and skeleton. Orthologous to human FOXA3 (forkhead box A3). PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced expression of several liver-specific and liver-enriched genes. Homozygous mice exhibit abnormal glucose homeostasis and reduced male fertility with abnormal spermatogeneis. Mice remodel their fat tissues on high fat diets, store less fat, and burn more energy as they age. Mutant mice live significantly longer than controls. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
