| Primary Identifier | MGI:88053 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 11812 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Acts upstream of or within cholesterol metabolic process and triglyceride metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in cerebral cortex ventricular layer; cortical plate; embryo; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal serum lipid levels on a chow diet, develop hypercholesterolemia only when fed a high-fat/high-cholesterol diet, and show significant increases in the liver content of cholesteryl esters and triglycerides and in biliary cholesterol concentration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
