| Primary Identifier | MGI:2675377 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 243874 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity. Involved in defense response to symbiont; positive regulation of interleukin-18 production; and pyroptotic inflammatory response. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Is expressed in early conceptus; intestine; ovary; and testis. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). PHENOTYPE: The protein protects against rotavirus infection. Homozygous KO leads to increased susceptibility to infection and greater severity of pathology. Mice homozygous for null alleles of Nlrp9a, Nlrp9b, and Nlrp9c exhibit reduced litter size, incomplete preimplantation lethality, delayed or impaired blastocyst formation, and failure of cell division at the 2 cell stage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
