Primary Identifier | MGI:1345193 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 23968 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable tubulin binding activity. Involved in several processes, including cortical granule exocytosis; cytoskeleton organization; and positive regulation of embryonic development. Acts upstream of or within several processes, including embryo implantation; regulation of RNA stability; and regulation of protein stability. Located in several cellular components, including apical cortex; nucleolus; and ooplasm. Part of subcortical maternal complex. Is expressed in early conceptus and ovary. Orthologous to human NLRP5 (NLR family pyrin domain containing 5). PHENOTYPE: Females lacking this maternal effect gene are sterile. Preimplantation embryos do not develop past the 2-cell stage. [provided by MGI curators] |