| Primary Identifier | MGI:2449088 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 260299 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme binding activity and vascular endothelial growth factor receptor binding activity. Involved in several processes, including negative regulation of cellular response to growth factor stimulus; negative regulation of protein phosphorylation; and regulation of Rac protein signal transduction. Predicted to be located in cell leading edge. Predicted to be active in cell-cell contact zone. Is expressed in dentate gyrus subgranular zone; dorsal root ganglion; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human CADM4 (cell adhesion molecule 4). PHENOTYPE: Mice homozygous for one null allele do not display myelination abnormalities. Mice with ubiquitous conditional deletion of the gene show myelination abnormalities, decreased nerve conduction velocity, hindlimb rigidity, limb grasping, and impaired coordination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
