| Primary Identifier | MGI:2152453 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 606496 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; and positive regulation of metabolic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be part of beta-catenin destruction complex. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including alimentary system; bone; central nervous system; craniofacial suture; and early conceptus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). PHENOTYPE: Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass. Mice homozygous for another null allele exhibit male infertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
