| Primary Identifier | MGI:104874 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 11652 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in negative regulation of PERK-mediated unfolded protein response and positive regulation of protein targeting to membrane. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and insulin receptor signaling pathway. Located in cell cortex and ruffle membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
