| Primary Identifier | MGI:1346093 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 23996 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable proteasome-activating activity. Acts upstream of or within blastocyst development. Part of proteasome accessory complex. Is expressed in several structures, including cranial ganglion; early conceptus; gonad; liver lobe; and submandibular gland primordium. Used to study amyotrophic lateral sclerosis. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele and a conditional allele activated in motor neurons develop ALS-like symptoms. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
