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Protein Coding Gene : Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Primary Identifier  MGI:104752 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  18036
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within cellular response to lipopolysaccharide; inflammatory response; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb; liver; maxillary process; and trunk somite. Orthologous to human NFKBIB (NFKB inhibitor beta).
PHENOTYPE: Mice homozygous for one knock-out allele exhibit decreased susceptibility to endotoxin shock and induced arthritis. [provided by MGI curators]
  • synonyms:
  • IkB,
  • IKappaBbeta,
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta,
  • Nfkbib,
  • MGD-MRK-28043
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