| Primary Identifier | MGI:1927664 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 64383 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NAD-dependent protein lysine deacetylase activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including cellular response to caloric restriction; positive regulation of cell cycle process; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; regulation of fat cell differentiation; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in several structures, including brain; liver; oocyte; sensory organ; and spinal cord. Orthologous to human SIRT2 (sirtuin 2). PHENOTYPE: Mice homozygous for a floxed allele activated in Schwann cells exhibit delayed myelination during development and following a nerve crush injury. Mice homozygous for a knock-out allele exhibit increased tumor formation and abnormal mitosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
