Primary Identifier | MGI:88113 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 11944 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables P-type potassium:proton transporter activity. Acts upstream of or within pH reduction; regulation of proton transport; and response to xenobiotic stimulus. Located in plasma membrane. Is expressed in body of stomach and stomach epithelium. Orthologous to human ATP4A (ATPase H+/K+ transporting subunit alpha). PHENOTYPE: Homozygous mutation of this gene results in achlorhydria, hypergastrinemia, and abnormalities of the parietal cells. Mice homozygous for an ENU-induced allele exhibit iron-deficiency anemia. [provided by MGI curators] |