Primary Identifier | MGI:95653 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 14447 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in flagellated sperm motility. Acts upstream of or within glycolytic process. Located in sperm fibrous sheath and sperm principal piece. Is expressed in cerebral cortex; heart; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). PHENOTYPE: Homozygous null mice display male infertility and asthenozoospermia. [provided by MGI curators] |