| Primary Identifier | MGI:96912 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17136 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ganglioside GT1b binding activity; protein homodimerization activity; and sialic acid binding activity. Involved in several processes, including central nervous system myelin formation; negative regulation of neuron apoptotic process; and positive regulation of myelination. Acts upstream of or within axon regeneration and transmission of nerve impulse. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and paranode region of axon. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein). PHENOTYPE: Homozygotes for targeted null mutations exhibit delayed CNS myelination, late myelin degeneration in peripheral nerves, hypomyelination of optic nerves, and subtle intention tremors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
