| Primary Identifier | MGI:2145955 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 105787 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; positive regulation of adipose tissue development; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; positive regulation of skeletal muscle tissue development; and regulation of peptidyl-serine phosphorylation. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is active in chromatin and late endosome. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; blastocyst; brain; and liver. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). PHENOTYPE: Mice homozygous for a null allele show reduced muscle cell glucose uptake, anemia, reticulocytosis, splenomegaly, increased erythrocyte turnover and plasma erythropoietin levels, and female subfertility associated with decreased litter size, reduced ovulation rate and a hyperandrogenic response. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
