Primary Identifier | MGI:1919231 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 71981 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Involved in several processes, including male meiotic nuclear division; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Part of PET complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human TDRD12 (tudor domain containing 12). PHENOTYPE: Homozygous males are infertile with small testes. Spermatogenesis is arrested predominantly at the pachytene spermatocyte stage. Retrotransposon hopping is derepressed in germ cells. [provided by MGI curators] |