| Primary Identifier | MGI:96562 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 16197 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable interleukin-7 receptor activity. Involved in defense response to Gram-positive bacterium. Acts upstream of or within several processes, including lymph node development; negative regulation of T cell mediated cytotoxicity; and positive regulation of T cell differentiation in thymus. Located in external side of plasma membrane. Is expressed in several structures, including adrenal gland; blastocyst-stage conceptus; gut; hemolymphoid system; and yolk sac. Human ortholog(s) of this gene implicated in colon cancer; lung non-small cell carcinoma; severe combined immunodeficiency; severe combined immunodeficiency 104; and stomach cancer. Orthologous to human IL7R (interleukin 7 receptor). PHENOTYPE: Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
