Primary Identifier | MGI:2681107 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233186 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monosaccharide binding activity and sialic acid binding activity. Involved in regulation of endocytosis. Located in lysosome. Orthologous to several human genes including SIGLEC5 (sialic acid binding Ig like lectin 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lung inflammation in response to ovalbumin challenge with increased eosinophils, delayed eosinophil resolution and impaired eosinophil apoptosis. [provided by MGI curators] |