| Primary Identifier | MGI:3613677 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 243961 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in dendritic spine; excitatory synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; and neocortex region. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). PHENOTYPE: Homozygous mutation of this gene results in smaller pyramidal neuron dendritic spines, smaller and thinner postsynaptic density of central excitatory synapses, weaker synaptic transmission, increased anxiety-related behavior, and impaired contextual fearmemory, but enhanced spatial learning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
