| Primary Identifier | MGI:1927230 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 223435 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of fat cell differentiation. Predicted to be located in cytosol. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone. Predicted to be extrinsic component of membrane. Is expressed in 1st branchial arch; central nervous system; dorsal root ganglion; jaw; and ovary. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 44 and autosomal dominant intellectual developmental disorder 63 with macrocephaly. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). PHENOTYPE: Homozygous mutant mice die during late embryonic development or shortly after birth. They exhibit abnormal skeletal myogenesis and display aberrant organization within the hippocampus and olfactory bulb. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
