| Primary Identifier | MGI:1916933 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 69683 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to contribute to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell migration; and positive regulation of endothelial cell proliferation. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human EMC10 (ER membrane protein complex subunit 10). PHENOTYPE: Mice homozygous for a gene trapped allele show improved glucose tolerance and reduced fertility in males, and an increased anxiety-related response in females. Homozygotes for a knock-out allele show female subfertility and male sterility associated with abnormal sperm morphology, oligozoospermia, asthenozoospermia, impaired capacitation and acrosome reaction, sperm incapacity to fertilize intact or ZP-free oocytes, and ion imbalance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
