Primary Identifier | MGI:1919210 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 71960 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). PHENOTYPE: Mice homozygous for a knock-out allele are healthy and survive to adulthood with no apparent defects. About 30% of knock-in mice either heterozygous or homozygous for a single amino acid mutation exhibit increased lymphoma incidence. [provided by MGI curators] |