| Primary Identifier | MGI:1351455 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 22121 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA binding activity. A structural constituent of ribosome. Involved in cellular response to type II interferon and negative regulation of translation. Acts upstream of or within several processes, including lung morphogenesis; macrophage chemotaxis; and response to lipopolysaccharide. Located in cytoplasm. Part of GAIT complex and cytosolic large ribosomal subunit. Is active in synapse. Is expressed in early conceptus. Orthologous to human RPL13A (ribosomal protein L13a). PHENOTYPE: Homozygotes lacking snoRNAs encoded by introns of this gene show altered mitochondrial metabolism, lower reactive oxygen species tone, enhanced glucose-stimulated insulin secretion and glucose tolerance, reduced oxidative stress responses in pancreatic islets, and resistance to diabetogenic stimuli. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
