| Primary Identifier | MGI:1354963 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 50722 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in negative regulation of testosterone biosynthetic process; penetration of zona pellucida; and positive regulation of apoptotic process. Acts upstream of or within canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in acrosomal vesicle. Is expressed in several structures, including extraembryonic component and reproductive system. Orthologous to human DKKL1 (dickkopf like acrosomal protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit increased sperm count associated with decreased spermatocyte apoptosis. Mice homozygous for a different knock-out allele exhibit decreased fertilization frequency in vitro and delayed fertilization in vivo. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
