| Primary Identifier | MGI:98341 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 20637 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable U1 snRNA binding activity; U1 snRNP binding activity; and mRNA binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and sensory organ. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic growth retardation and lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
