| Primary Identifier | MGI:95589 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 14325 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion transport. Predicted to be located in autolysosome. Predicted to be part of ferritin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ciliary body; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). PHENOTYPE: Mice homozygous for a null allele display partial lethality during organogenesis, decreased circulating, liver and reticuloendothelial cell iron levels, head tilt, and unidirectional circling. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
