| Primary Identifier | MGI:1913315 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66065 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Predicted to be involved in steroid catabolic process. Predicted to be active in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). PHENOTYPE: In a high-throughput phenotyping screen, male null mice exhibit infertility, decreased sperm production, testicular degeneration and an increased anxiety-like response to stress-induced hyperthermia. Homozygous null mice also show an increase in serum IgG2a in response to antigen challenge. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
