| Primary Identifier | MGI:106581 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 22088 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced growth, fail to form mesoderm, accumulate p53 protein and die by embryonic day 6.5. Homozygotes for a mammary gland-specific knockout show impaired mammogenesis and are unable to nurse their pups. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
