| Primary Identifier | MGI:1338801 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 20430 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables translation repressor activity. Involved in several processes, including dendrite extension; positive regulation of neurotrophin TRK receptor signaling pathway; and regulation of modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly. Located in lamellipodium; neuron projection; and perinuclear region of cytoplasm. Is active in postsynapse. Is expressed in several structures, including embryo mesenchyme; lung; nervous system; skeletal muscle; and tooth. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). PHENOTYPE: Mutations at this locus result in embryonic lethality before the turning stage in homozygotes. Heterozygotes exhibit abnormal synaptic transmission. Parental origin of the mutant allele in heterozygotes has an effect on long term depression, cued fear conditioning, anxiety, and activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
