Primary Identifier | MGI:2661187 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233335 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables intermediate filament binding activity. Acts upstream of or within fast-twitch skeletal muscle fiber contraction. Located in neurofilament cytoskeleton and sarcolemma. Is expressed in several structures, including adipose tissue; genitourinary system; gut; musculature; and nervous system. Orthologous to human SYNM (synemin). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a mild skeletal muscle phenotype characterized by abnormal muscle fiber morphology and increased sarcolemmal deformability and susceptibility to injury. [provided by MGI curators] |