| Primary Identifier | MGI:1914344 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 54608 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and nuclear steroid receptor activity. Involved in acrosome reaction. Acts upstream of or within negative regulation of smooth muscle cell migration and response to wounding. Located in acrosomal vesicle. Is expressed in several structures, including cardiovascular system; central nervous system; endocrine gland; genitourinary system; and sensory organ. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit enhanced migratory ability of cultured smooth muscle cells and significant intimal hyperplasia after cuff placement. Homozygotes for a null allele show altered ovarian follicle maturation, an increased number of atretic antral follicles, and a dysregulated estrous cycle with a prolonged estrus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
