| Primary Identifier | MGI:1918252 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 108797 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including positive regulation of GTPase activity; positive regulation of phagocytosis; and protein localization to cell cortex. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cartilage; cranium; and reproductive system. Orthologous to human MEX3B (mex-3 RNA binding family member B). PHENOTYPE: Homozygous inactivation of this gene leads to partial neonatal lethality, decreased body weight and subfertility. Males show seminiferous tubule obstruction, oligozoospermia, abnormalities in Sertoli cell barrier morphology and function, and impaired Sertoli cell and macrophage phagocytosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
