| Primary Identifier | MGI:1858193 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 53320 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables carboxypeptidase activity and dipeptidase activity. Acts upstream of or within folic acid-containing compound metabolic process and proteolysis. Located in plasma membrane. Is expressed in central nervous system; male reproductive gland or organ; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1). PHENOTYPE: Homozygous mutation of this gene results in protection from peripheral neuropathy and ischemic brain injury. Homozygotes for a null allele show increased food intake, anxiety-like behavior, smaller sciatic nerve axons, and impaired angiogenesis. Homozygotes for a different null allele show less neuron degeneration and astrocyte damage after traumatic brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
