| Primary Identifier | MGI:1354184 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 50490 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption and cardiac muscle cell differentiation. Located in cell periphery; mitochondrion; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH oxidase 4). PHENOTYPE: Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis. Another homozygous knockout suppresses inflammatory reactions and reduces susceptibility to LPS-induced acute kidney disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
