| Primary Identifier | MGI:2447063 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 23966 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein homodimerization activity. Involved in several processes, including central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in several cellular components, including neuron projection; nucleus; and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; future brain; somite; and upper leg. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
