| Primary Identifier | MGI:1333854 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 14389 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of epithelial cell migration; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Located in membrane raft. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to human GAB2 (GRB2 associated binding protein 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit impairments in passive cutaneous and systemic anaphylaxis, Fc gamma receptor-mediated phagocytosis, and mast cell development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
