| Primary Identifier | MGI:1913440 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66190 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Involved in ceramide catabolic process; inflammatory response; and sphingosine biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in hair; integumental system; vibrissa; and vibrissa follicle. Orthologous to human ACER3 (alkaline ceramidase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered homeostasis of ceramides and their sphingolipid derivatives in the aging brain resulting in Purkinje cell degeneration, decreased vertical activity, limb grasping, and impaired motor coordination and balance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
