| Primary Identifier | MGI:1099787 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 22229 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in lipid hydroperoxide transport and proton transmembrane transport. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrial inner membrane. Is expressed in adipose tissue; heart; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). PHENOTYPE: Homozygous null mutants exhibit a lack of superoxide-induced uncoupling in skeletal muscle mitochondria, accompanied by increased reactive oxygen species formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
