Primary Identifier | MGI:2443373 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 320100 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in amelogenesis. Predicted to be located in nucleoplasm. Is expressed in female associated reproductive structure and urethra of female. Used to study amelogenesis imperfecta type 3C. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). PHENOTYPE: Mice with a premature termination codon resulting in a null allele exhibit incisor and molar enamel malformations. Homozygous knockout affects T cell proliferation and reduces tumor growth. [provided by MGI curators] |