| Primary Identifier | MGI:2441741 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 223864 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables guanyl-nucleotide exchange factor activity. Involved in associative learning. Predicted to be located in several cellular components, including actin-based cell projection; basolateral part of cell; and distal axon. Predicted to be active in plasma membrane. Predicted to colocalize with cortical actin cytoskeleton. Is expressed in brain; heart; lens; lung; and metanephros. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased induced neuron apoptosis. Mice homozygous for a different allele exhibit impaired glucose homeostasis with decreased insulin secretion, increased susceptibility to diet-induced obesity and streptozotocin-induced insulitis and hyperglycemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
